IDH2 and cancer: Cancer‐associated IDH mutations result in the accumulation of the oncometabolite 2‐hydroxyglutarate (2‐HG), a molecule that dysregulates many biochemical pathways including DNA, RNA and histone methylation, collagen maturation, hypoxic signaling, and DNA repair (Losman & Kaelin, 2013; Molenaar et al, 2018).