While the use of adrenergic receptor agonists on both human and murine immune cells leads to decreased production of cytokines (TNF-α, IL-6, IL-12, and IFN-γ) and increased migration (149, 152), there is limited information on how SNS signals affect either BM immune cells or HSPCs during inflammatory stress and obesity. Here, IL6 is linked to obesity due to melanocortin 4 receptor deficiency.