ZC3HC1 and Stroke: When we performed an analogous analysis focused on genes previously associated with three relevant traits – MI, heart failure and stroke, we identified a novel heart eGene, ZC3HC1, encoding the NIPA protein, which is implicated in MI, coronary artery disease, and ischemic stroke (IBC 50K CAD Consortium, 2011; Nikpay et al., 2015; Schunkert et al., 2011).