It shows a broad phenotype with predominant immunological involvement: recurrent infections, atopic disease, psychomotor disability, failure to thrive, skeletal abnormalities, eosinophilia, high levels of serum immunoglobulin E (IgE) (hyper-IgE) and decreased counts of cluster of differentiation 4 (CD4) T-cells, besides many other signs/symptoms present in a minority of the patients. This evidence concerns the gene IGHE and Failure to thrive.