KL and hyperphosphatemia: α‐Klotho (referred to herein as Klotho) was first reported by Kuro‐o and colleagues.(71) Its disruption in mice is associated with soft tissue calcification, profound hyperphosphatemia, osteoporosis, emphysema, arteriosclerosis, skin atrophy, infertility, hypoglycemia, and a curtailed lifespan.