KL and Hypertension: In vivo, Klotho gene delivery similarly attenuates NADPH oxidase activity and superoxide production to prevent the progression of spontaneous hypertension and resulting renal damage.(87) These findings led us to propose that 1,25(OH)2D/VDR–RXR primary induction of Klotho mRNA represents a natural pathway to maintaining healthful aging, with intracellular calcium current regulation and mitigation of oxidation being common themes.