AKT1 and prostate neoplasm: Thus, through PI3K/AKT signaling, OPN upregulates MZF1, likely via an AKT pathway to elicit the occupation of c‐myb and AP4 elements that have been shown to be functional within the MZF1 proximal promoter region.(142) Notably, Chen and colleagues(142) reported that enhanced MZF1 expression suppresses prostate tumor cell growth by promoting ferroportin‐driven iron egress as a result of MZF1 induction of ferroportin.