ALB and Cirrhosis: The relationship between free 25OHD and total 25OHD is both steeper and more variable in patients with liver disease than in healthy people.(27) Those with the most‐severe cirrhosis and protein synthesis dysfunction have a higher percentage of free 25OHD compared with cirrhotics without protein synthesis dysfunction, but free 25OHD concentrations are similar because of the presence of both lower total 25OHD concentrations as well as lower DBP.(59) Free 25OHD concentrations range between 4.5 to 8.1 pg/mL in cirrhotics with low albumin and from 6.4 to 10.6 pg/mL in those with normal albumin.