That said, one cannot conclude that these binding globulins have no role other than hormone transport as is well‐demonstrated by the ability of DBP to serve as an actin scavenger or as part of the macrophage activating factor, TTR to transport thyroid hormones into the cerebrospinal fluid, possible role of SHBG to transport sex steroids into the placenta, or CBG to deliver increased cortisol to sites of infection (via cleavage by neutrophil elastase). The gene discussed is ELANE; the disease is infection.