We have shown that heptamer-type sgRNAs designed to target the human BCL2 or WT1 mRNA efficiently induce apoptosis in human leukemia cells and that heptamer-type sgRNAs designed to target the human BCL2 or CCND1 mRNA efficiently trigger apoptosis in human myeloma cells [[20], [21], [22]]. This evidence concerns the gene BCL2 and plasma cell myeloma.