CD274 and hepatocellular carcinoma: Most recently, a regimen combining bevacizumab with atezolizumab, an anti-programmed death ligand 1 (PD-L1) antibody, received clinical approval as a first-line systemic therapy for unresectable HCC, based on its phase III trial (IMbrave150) reporting an objective response rate of 36%, along with better overall survival compared with sorafenib, the prior standard of care[5].