APC and hepatocellular carcinoma: As a proof of concept with regard to phospholipid metabolism, a recent series of experiments performed in an adenomatous polyposis coli (APC) knock-out mouse model of β-catenin activated HCC suggests that tumor uptake of fluorocholine (FCH), a fluorine-18 labeled PET radiopharmaceutical analog of choline used for in-vivo tracing of tissue phosphatidylcholine synthesis[51,52], is strongly influenced by β-catenin activation[28].