CTNNB1 and hepatocellular carcinoma: Furthermore, our previous published analysis of this radiogenomic dataset[54] reported that tumors displaying high FCH uptake disproportionately expressed gene signatures corresponding to distinct molecular classes of HCC, including the S3 class described by Hoshida et al. [62]; the G5 and G6 classes described by Boyault et al. [63]; and the “CTNNB1-activated” class described by Chiang et al. [64].