In addition to experiencing higher rates of progressive disease, ICI-treated HCC patients with CTNNB1 or AXIN1 mutated tumors also experience significantly shorter progression free survival (median 2.0 months vs. 7.4 months, HR = 9.2, 95%CI: 2.9-28.8, P < 0.0001)[16]. The gene discussed is CTNNB1; the disease is hepatocellular carcinoma.