ARLN and otitis media with effusion: ALN induced a rise in secretion of IL-6 from osteoblasts after three days (p = 0.008), whereas a decline to 70% and 50% of control was seen at day three after incubation with OME (p = 0.010) and ALN + OME (p ≤ 0.001), respectively (Fig. 3A).