In breast cancers, SOX2 is up-regulated by the transcription factor FOXO1 (Forkhead box protein O1) (62), the long non-coding RNA SOX2OT (SOX2 overlapping transcript) (63), and the EGFR/Stat3 signaling pathway in a paracrine manner involving tumor-associated macrophages (64). This evidence concerns the gene STAT3 and breast cancer.