TERT and cancer: A main player in the activation of this pathway in tumor cells is the cMyc oncogene that, among its multiple transforming properties, works as a positive transcriptional regulator of TERT gene, constituting a key signaling axis in cancer (3, 4); once this is switched on, active telomerase triggers cell immortalization by preventing telomeres shortening, thus resulting in the abrogation of replicative senescence (1).