Both in the rat model of cardiac hypertrophy induced by transverse aorta constriction and in hypertrophic cardiomyocyte models treated with different inducing reagents endothelin-1 or phenylephrine, the expression of miR-223-3p in myocardium and cardiomyocytes were downregulated (124, 125). This evidence concerns the gene EDN1 and cardiac hypertrophy.