These effects of miR-223-3p on macrophage activation and polarization made contributions to alleviating CVB3-induced inflammation and myocarditis with reducing pro-inflammatory and myocardial injury markers including interferon-γ, interleukin 6 (IL-6), creatine kinase MB, lactate dehydrogenase, and aspartate transaminase, as well as increasing the anti-inflammatory factor interleukin 10. The gene discussed is IL6; the disease is myocarditis.