Thus, SARS-CoV-2 entry is expected to shift the RAS balance from the protective ACE2-Ang-(1-7) arms to the detrimental ACE-Ang-II axis, implying that the inhibition of atherosclerosis from ACE2/Ang-(1-7) is weakened, however, acceleration of atherosclerosis from Ang-II is enforced. The gene discussed is ANG; the disease is atherosclerosis.