C3 and diabetic kidney disease: Canonical pathway analysis noted that within the complement system, C3, CD55, C1QA, CD46, C1QB, CFB, C4A/C4B, C7, CFH, C3AR1, CR1, and C2 in DKD glomeruli showed a three-fold increase in their expression compared to healthy controls indicating complement is likely locally synthesized within the DKD glomerulus (60).