The analysis of RNA is particularly important for the detection of gene fusions that may have breakpoints within large repetitive element-rich introns, as is the case for ROS1, NTRK2, and NTRK3 gene fusions, which are predictive of response to specific kinase inhibitors, including in NSCLC (57, 58). The gene discussed is ROS1; the disease is non-small cell lung carcinoma.