The currently known genetic alterations associated with CC involve the ErbB-3 (Di et al., 2015; Cancer Genome Atlas Research Network et al., 2017), epidermal growth factor receptor (EGFR) (Wei et al., 2018), Serine/Threonine Kinase 11 (STK11) (Hirose et al., 2020), transforming growth factor-beta receptor 2 (TGFBR2) (Cai et al., 2018), phosphatase and tensin homolog (PTEN) (Nero et al., 2019), etc. Nevertheless, the underlying mechanisms of CC carcinogenesis and progression still remain elusive so far. This evidence concerns the gene PTEN and cancer.