ACSL3 and cancer: While acyl-CoA synthetase long-chain family member 3 (ACSL3) is not a biomarker of ferroptosis, ACSL3-mediated monounsaturated fatty acids (MUFAs) production limits oxidative PUFA-mediated ferroptosis in certain cancer cells (Magtanong et al., 2019), indicating that ACSL4- or ACSL3-dependent fatty acid metabolism plays opposite roles in ferroptosis.