Some studies have found monoallelic deletion of DHRS3 in some neuroblastoma cell lines, but others have shown that DHRS3 is constitutively expressed in breast cancer cell lines and highly expressed in papillary thyroid carcinoma (Haeseleer et al., 1998; Oler et al., 2008). Here, DHRS3 is linked to thyroid gland papillary carcinoma.