A recent study has revealed the molecular consequences of OI-linked full-length PLS3 variants (p.E249_A250insIMGHSHSGSCLL, p.A253_L254insN, p.A368D, p.N446S, and p.L478P) at the protein and cellular levels (Schwebach et al., 2020). Here, PLS3 is linked to osteogenesis imperfecta.