CCN4 and colorectal neoplasm: Although discrepancies exist in CRC studies, as for instance Khor et al. (2006) demonstrated WISP1 enrichment in well-differentiated colorectal tumors while Davies et al. (2010) showed association of higher WISP1 expression with poorly differentiated tumors, there is strong evidence from both studies that WISP1 plays a role in promoting CRC progression and aggressiveness.