Previous studies revealed that WISP1 was highly expressed in a variety of cancers, including prostate cancer (Ono et al., 2013; Gaudreau et al., 2019), breast cancer (Chiang et al., 2015), lung cancer (Chen et al., 2015), and melanoma (Deng et al., 2019), suggesting that WISP1 may promote oncogenesis. Here, CCN4 is linked to melanoma.