RNF180 and neoplasm: Remarkably, lower expression of RNF180 in patients was accompanied with larger tumor size (p = 0.0087), advanced overall pathological stage (T, N, and M) (p = 0.0025, 0.0011, 0.0065, respectively), and advanced TNM stage (p = 0.0014) (Figure 1E), whereas the expression of RNF180 was not associated with patient age, gender, or histologic differentiation (data not shown).