In summary, we speculate that mitochondrial tRNA 15910 C>T impairs mitochondrial function, increases ROS production, downregulates the expression of APN and its receptor AdipoR1, and then suppresses the expression of PGC-1α and elevated ERRα via the mutual regulation between ERRα and PGC-1α, consequently resulting in further mitochondrial dysfunction and high blood pressure. This evidence concerns the gene ESRRA and hypertensive disorder.