We found that NKAP mediated the proliferation and apoptosis of human NB cells through activating the phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathways, and the expression of NKAP may act as a novel biomarker for predicting recurrence and chromosome 11q deletion in patients with NB. This evidence concerns the gene AKT1 and neuroblastoma.