For instance, in gastric cancer, EVs containing miR155, miR193b, and miR210 prime CAFs to secrete inflammatory chemokines, such as CXC ligand (CXCL)-1 and CXCL-8, through the activation of the Janus kinase (JAK)/STAT and NF-κB signaling pathways (Naito et al., 2019). This evidence concerns the gene CXCL8 and gastric cancer.