Similarly, CXCL-1 and CXCL-8 positivity in CAFs was significantly associated with poor prognosis in gastric cancer patients (Naito et al., 2019), whereas CXCL-8,−10, and−11 CAFs expression correlated with resistance to neoadjuvant CT and poor prognosis in BC (Xu et al., 2020). Here, CXCL8 is linked to breast cancer.