Indeed, KRAS mutant but not KRAS wild-type pancreatic ductal adenocarcinoma (PDAC) cancer cells induce CAFs activation through CXCR-2, leading to a nuclear factor-kappa B (NF-κB)-mediated secretion of pro-tumoral cytokines interleukin (IL)-4, IL-10, and IL-13 (Awaji et al., 2020). This evidence concerns the gene KRAS and cancer.