IL6 and cancer: An inflammatory CAFs subtype (iCAFs), distant from cancer cells, showed a secretory phenotype with high interleukin and chemokine production [leukemia inhibitory factor (LIF), IL-6, IL-11, IL-1, CXCL-1] in comparison with periglandular myofibroblastic CAFs (myoCAFs), specialized in stromal remodeling functions (Öhlund et al., 2017).