Similarly, in BC (Figure 2), a subset of myofibroblastic CAFs (CAF-S1: CD-29Med FAPHi FSP-1Low−Hi αSMAHi PDGFRbMed−Hi CAV-1Low) secreting differentially higher amount of CCL-11, CXCL-12, CXCL-13, and CXCL-14 was predominantly detected close to epithelial tumor cells (Costa et al., 2018). This evidence concerns the gene CXCL12 and breast cancer.