Another cardiac-specific miRNA (Seok et al., 2014; Wang et al., 2015; Su et al., 2016), miR-208a, inhibits T3-mediated signaling pathway by repressing the THs Associated Protein/Mediator Complex Subunit 13 (THRAP1/MED13) in a mouse model of cardiac hypertrophy and hypothyroidism (van Rooij et al., 2009; Neppl and Wang, 2014; Figure 2B). The gene discussed is MED13; the disease is cardiac hypertrophy.