Our group has previously reported that BRG1, recruited by NF-κB, directly binds to the promoters of pro-inflammatory mediators in hepatocytes exposed to excessive nutrient influx and drives hepatic inflammation in the pathogenesis of non-alcoholic steatohepatitis (Tian et al., 2013). Here, NFKB1 is linked to metabolic dysfunction-associated steatohepatitis.