IFNG and Hepatitis: Congruently, ablation of interferon gamma (IFN-γ, encoded by IFNG), a prototypical T cell cytokine, or its cognate receptor (IFNGR1/R2), or its downstream mediator IRF-1 attenuates ConA-induced hepatitis in mice (Ohta et al., 2000; Hong et al., 2002; Jaruga et al., 2004).