Sun et al. (2016) have found that BRG1, as a component of a large chromatin remodeling complex that also including ARID1 and BRM, contributes to liver regeneration at least in part by regulating the transcription of inflammation-related genes in hepatocytes. More recently, Huang et al. (2019) have reported that the non-coding RNA MALAT1 binds to and directs BRG1 to the IL-6 and CXCL8 loci in hepatocellular carcinoma (HCC) cells in response to LPS stimulation thereby promoting oncogenic transformation. The gene discussed is MALAT1; the disease is hepatocellular carcinoma.