By contrast, the BMD, TBV/TV, Tb.N, and Tb.Th thickness were decreased significantly while the Tb.Sp and SMI thickness were increased markedly in OVX mice treated with agomiR-miR-29b-3p and si-SOCS1 injection compared to those in OVX mice with only agomiR-miR-29b-3p injection (Figures 5A,B), thus confirming that these mice had osteoporosis. This evidence concerns the gene SOCS1 and osteoporosis.