We further compared the key molecules to the top 50 changed transcripts in the SCA2 mouse model (Dansithong et al., 2015) and found that RGS8 is the unique dysregulated gene in the four different SCA mouse models (Figure 1C), with a reduced expression on SCA1, 2, and 7, but an increased expression in SCA14. This evidence concerns the gene RGS8 and autosomal dominant cerebellar ataxia.