Also, Hsp90/peptide complexes purified from tumors (particularly ER Hsp90 resident: the glycoprotein 96 [gp96]) showed to be effective when employed as therapeutic vaccines in several animal models, producing an antitumoral immune response, including tumor rejection and inhibition of metastatic tumor progression (Srivastava et al., 1998). The gene discussed is HSP90AB1; the disease is metastatic neoplasm.