We compared these genes above with genes differentially expressed in BA patient livers based on published RNA-seq data (19), and we found that many YAP downstream genes, such as ANKRD1, CTGF, AMOTL2, PALMD, ANXA3, CYR61, NEDD9, TNFRSF12A, and KLF5, were highly expressed in BA livers (Supplementary Figure 1A). The gene discussed is CCN1; the disease is breast angiosarcoma.