CYP2R1 and type 2 diabetes mellitus: A Mendelian Randomization analysis in 96,423 Danish individuals examined four genetic polymorphisms in the DHCR7 and CYP2R1 genes in relation to T2D [24], where the DHCR7 allele score (rs11234027 + rs7944926) showed a significant association with increased risk of T2D (P for trend = 0.04); but there were no significant associations between CYP2R1 SNPs or allele scores and risk of diabetes [24].