A similar pattern of association was seen where only five significant associations were reported for vitamin D synthesis-related genes (DHCR7 and CYP2R1) as compared to the vitamin D metabolism-related genes (CYP24A1, GC and VDR), where 30 significant associations were observed, and, in particular, 26 significant associations with T2D was seen for the VDR SNPs. This evidence concerns the gene CYP2R1 and type 2 diabetes mellitus.