There have been only two studies [28, 38] that examined SNPs from vitamin D activating CYP27B1 gene in relation to T2D and both the studies, the prospective case-cohort study in 53,088 Germans [28] and a cross-sectional study in 522 individuals from a Polish population [38], failed to show an association of CYP27B1 SNPs, rs10877012 and rs184712, with T2D, respectively. Here, CYP27B1 is linked to type 2 diabetes mellitus.