Nominal significant associations were reported with obesity traits in the Chinese study for CYP2R1 rs10832313 polymorphism; however, this did not remain significant after correction for multiple testing [20] and no significant associations were reported for DHCR7 SNP rs12785878 in the African population [21]. This evidence concerns the gene CYP2R1 and obesity due to melanocortin 4 receptor deficiency.