RNase7 (fold change 2, IQR 1–3, CRAPome 0%, p=0.05), S100B (fold change 5, IQR 3-9, CRAPome 0, p=0.03), S100A4 (fold change 5, IQR 4-5, CRAPome 2%, p=0.01), and S100A2 (fold change 14, IQR 7–24, CRAPome 1%, p=0.05) were significantly increased in the MS skin but not in MSOA skin, where they were either decreased or undetectable (Figure 6). This evidence concerns the gene S100A4 and myeloid sarcoma.