Loss-of-function mutations in TP53, PTEN, and/or RB1 in GFAP-CreER mice (50) and injection of shNF1-shp53- or H-RasV12-shp53 lentivirus in the cortex of GFAP-cre resulted in glioma formation (51). The gene discussed is PTEN; the disease is central nervous system cancer.