Complete loss of Dicer is incompatible with life (4, 17, 18), while somatic mosaic mutations in the RNase IIIb domain have been associated with a more serious form of DICER1 syndrome, named GLOW syndrome from Global developmental delay, Lung cysts, Overgrowth, and Wilms tumor (19). This evidence concerns the gene DICER1 and DICER1-related tumor predisposition.