However, Ameri et al., showed that a member of the same family—HIGD1A (HIG1 hypoxia inducible domain family member 1A) interacts with the electron transport chain, modulating mitochondrial ROS production, oxygen consumption, and AMPK activity to promote survival during glucose starvation, while simultaneously decreasing tumor growth in vivo (52). Here, PRKAA1 is linked to neoplasm.