Especially in caspase-3 mutated cancer cells resistant to either multidrug (e.g. doxorubicin, cisplatin, and paclitaxel) or Ce6-PDT when the autophagic flux is chemically inhibited (e.g. 3-MA or BAF-A1), the tumor relapse increases up to 50% (166). This evidence concerns the gene CASP3 and neoplasm.