WNT1 and breast cancer: The use of these nanoparticles to carry doxorubicin, i.e., TAM-targeting DOX-AS-M-PLGA-NPs, demonstrates a more potent effect than DOX alone or DOX-AS-PLGA-NPs in controlling the tumor growth of the orthotopic MMTV-M-Wnt-1 mammary tumor-bearing mouse model (50).