For example, a study used MDA-MB-231 cells, MCF-7 breast cancer cell lines, and 4T1 cell-bearing mice as models to study the anti-cancer effect of the co-delivery of GA and TNF-related apoptosis-inducing ligand (TRAIL) plasmid by hyaluronic acid grafted PEI-PLGA nanoparticles (GA/pTRAIL-HA/PPNPs) (37). The gene discussed is TNFSF10; the disease is cancer.