The GO annotation and KEGG pathway analyses (Figures 1B, C) indicated that many target genes are involved in a variety of cellular pathways, among which, the Hippo pathway is involved in the progress of ICC, and the expression of the main effector molecule, YAP1, in ICC is significantly elevated compared to corresponding para-tumor tissue. This evidence concerns the gene YAP1 and intrahepatic cholangiocarcinoma.