We further evaluated the relationship between CMTM6 expression and TMB and showed that CMTM6 expression was correlated with TMB in COAD, ESCA, acute myeloid leukemia (LAML), LIHC, SARC, and STAD (Figure 4A), while no relationship was observed in the other 27 cancers (Figure S3). Here, CMTM6 is linked to cancer.