The ectopic expression of RBM8A in MHCC97H/OXA HCC cells induced loose cell contact and spindle-shaped morphology reminiscent of EMT, whereas RBM8A knockdown in Bel7404/OXA cells resulted in a dramatic shift in the cell morphology from loose cell growth to a tighter cell-cell adherence characteristic of epithelial cells. This evidence concerns the gene RBM8A and hepatocellular carcinoma.