Among these women, 71.00% (502) patients were aged 50 or older, 68.32% (483) patients were in N1 status, 71.43% (505) patients were ER negative (ER-), 79.63% (563) patients were PR negative (PR-), and 75.81% (536) patients had only one primary breast cancer. The gene discussed is ESR1; the disease is breast carcinoma.