CD4 and hepatocellular carcinoma: Notably, we found that more activated CD4+ T cell (HR = 1.41, 95% CI = 1.00 - 2.00, P = 0.049) and more central memory CD4+ T cell (HR = 1.42, 95% CI = 1.02 - 2.02, P = 0.041) subpopulations were associated with dismal prognosis in HCC (Figures 3A, B).