In adaptive immunity, the enrichment of central memory CD4+ T cells (370/370), Th1 cells (338/370), activated CD8+ T cells (338/370), γδ T cells (298/370), and effector memory CD8+ T cells (265/370) constituted the most abundant immune infiltrates in HCC, whereas the fraction of effector memory CD4+ T cells (1/370), Th17 cells (0/370), and tumor infiltrating-B cells (28/370) was significantly lower in HCC. The gene discussed is CD4; the disease is hepatocellular carcinoma.