[25] In addition, the WEE1 yeast homolog Swe1WEE1 was recently reported to act as a histone‐sensing checkpoint by sensing excess histone levels before cells enter mitosis, thus preventing aberrant chromosomal segregation and polyploidy.[26] Thus, WEE1 targeting might affect several key cellular processes that are particularly relevant in cancer cells as they proliferate at high rates and are more prone to replication stress with higher demands in dNTP and histones. The gene discussed is WEE1; the disease is cancer.