One of the most important signs of immunogenic death is the translocation of calreticulin from the endoplasmic reticulum to the outside of the cell membrane, promoting the phagocytosis and presentation of tumor antigens by dendritic cells, thereby effectively initiating specific antitumor immune responses.[28, 29, 30] Due to the important role of immunogenic death in cancer immunotherapy, the development of drugs that induce immunogenic death of cancer cells has been receiving much attention.[29, 31, 32, 33] However, effective immunogenic death inducers are currently very limited. This evidence concerns the gene CALR and cancer.