The major conclusions from the study of the novel SynB3‐PVGLIG‐PTX nanocomplex were that (Figure 10): 1) SynB3‐PVGLIG‐PTX exhibited a strong affinity with MMP‐2, and it could enhance water solubility by agglomerating to form a special structure with a positive charge; 2) a controlled release of PTX from SynB3‐PVGLIG‐PTX occurred upon cleavage of MMP‐2, implying that SynB3‐PVGLIG‐PTX has a specific cytotoxicity in GBM cells; 3) SynB3‐PVGLIG‐PTX can effectively inhibit the proliferation, migration, and invasion of GBM cells in vitro and in vivo. Here, MMP2 is linked to glioblastoma.