Based on these observations, we confirmed that SynB3‐PVGLIG‐PTX has a specific antigrowth activity, that is, only in the presence of MMP‐2, the sensitive linker (PVGLIG) contained in SynB3‐PVGLIG‐PTX can be specifically hydrolyzed to release PTX, thereby inhibiting the proliferation of GBM cells. This evidence concerns the gene MMP2 and glioblastoma.