MMP2 and glioblastoma: In recent years, numerous insightful studies have demonstrated that MMP‐2 is over‐expressed in GBM and has a characteristic ability to recognize and cleave peptides with specific sequences.[28, 29, 35] As such, various substrates of MMP‐2 were designed to enhance specificity for drug delivery, thus leading to a remarkable effort toward the investigation of drug‐targeted delivery systems.