There were 9 pathogenic variants of ACMG, including W746C in GAA in patients with CHD, R218Q KCNJ2 and R5338X TTN in patients with iVT, and F244L MYH7, Q353X LMNA, L17465X TTN, W21011X TTN, c.2334+1G >A DSG2, c.477+1G >A KCNQ1 in patients with DCM (Table S2). The gene discussed is DSG2; the disease is familial dilated cardiomyopathy.