Intermittent hypoxia and hypercapnia during sleep caused by OSAS may result in sympathetic nervous system activation, renin-angiotensin-aldosterone system activation, vascular endothelial dysfunction, oxidative stress, and metabolic dysregulation [3], which are considered to be associated with the development of cardiometabolic diseases such as hypertension and type 2 diabetes mellitus (T2DM) [4, 5]. This evidence concerns the gene REN and type 2 diabetes mellitus.