We additionally enrolled EMT-related markers including ZEB1/2, β-catenin and TWIST1/2 and put them into analysis together with IKBIP. Subsequent Circos plots in both CGGA and TCGA congruently revealed that IKBIP expression was especially correlated with TWIST1 in both pan-glioma and GBM (Figure 7). This evidence concerns the gene TWIST1 and central nervous system cancer.