In addition to autoimmune T and B cells, plasmacytoid dendritic cells (pDCs) play a prominent role in lupus through type I IFN production, namely IFN‐α, downstream of innate immune recognition of self‐DNA and ‐RNA through toll‐like receptors (TLRs).143, 144. This evidence concerns the gene IFNA1 and systemic lupus erythematosus.