Compared to patients without AKI, AKI patients were characterized by a higher proportion with diabetes, a higher POSSUM physiological score, higher use of combined spinal anesthesia with patient-controlled analgesia (PCA), a lower preoperative haemoglobin, higher red cell transfusion requirement intra-operatively, and a higher C-reactive protein (CRP) (Table 1). The gene discussed is CRP; the disease is acute kidney injury.