SIRT1 and major depressive disorder: It is noticeable that there exist medicines increasing SIRT1 activity, for example, resveratrol [152] or salvianolic acid B [154], which can promote correction of redox imbalance through an increase in activity of Nrf2 [154] and, likely, FoxO, as well as through a decrease in the activity of NF-κB. However, an increase in the activity of SIRT1 in the nucleus accumbens may favor anxiety- and depression-like behaviors [152].